What We Fund. What We've Found. Where We're Going.
The Grant Program
Violehealth makes investigator-initiated grants to academic and clinical researchers advancing the science of KCNQ2 loss-of-function disorders. We prioritize work with a clear path from mechanism toward therapy.
Inquire about a grantPriority Research Areas
1.
Functional characterization of p.R325M via patch-clamp electrophysiology.
2.
AAV-based KCNQ2 supplementation in iPSC-derived neurons.
3.
Suppression–replacement (SupRep) gene therapy models.
4.
PIP₂ pathway pharmacology.
Current Projects
Functional Characterization of p.R325M (Patch-Clamp Electrophysiology)
To be awarded · To be determined
Patch-clamp electrophysiology to characterize how the R325M substitution disrupts PIP2 binding and the M-current, establishing the first functional data for this variant.
AAV-Based KCNQ2 Supplementation in iPSC-Derived Neurons
To be awarded · To be determined
Testing AAV delivery of healthy KCNQ2 copies in patient-derived iPSC neurons as a gene-supplementation strategy for dominant-negative loss-of-function variants.
Research Partners
Progress Timeline
2025
Foundation Founded
Violehealth is established in honor of Violetta.
2026
First Grant Cycle Opens
Investigator-initiated grants for KCNQ2 loss-of-function research.
Next
First Research Published
Functional data for the R325M variant.
?
Toward Therapy
Bridging mechanism to clinical translation.